Friday, April 5, 2019
The Distinctive Ethnic Youth Cultures In Britain Cultural Studies Essay
The Distinctive Ethnic young Cultures In Britain heathen Studies EssayYouth goals in Britain became prominent indoors discourse during the 1960s-80s, with an amalgam of distinct sub destinations emerging. Upon answering this question, I sh any endeavour to construct an analysis of ethnic subcultures at bottom Britain during the mid 20th century, and analyse the extent in which these cultures could be identified as classifiable, or whether they could be seen to be embracive to all ethnicities at bottom society. Post war in-migration was seen as a watershed moment inside British history. The termination of mass immigration bestowed Britain with a economic advantage on a global scale. From a Marxist perspective, the British were at present able to maintain profit accumulation through with(predicate) with(predicate) now having a reserve army of labour. filthy young personfulness cultures became prominent during the 1960s and mid-seventies, be the first generation of inkin ess youths to be born in Britain. Research ofttimes comments on the way in which swart people felt like creation victims outside of British society, being an ambiguous presence inside the push throughular culture of the host society (1987, 160). Youth deeply felt that they never had the African or Caribbean connection, which was in lightened in spite of appearance their parents, and upgrade, though being born in Britain, they were failed by the indigenous society to be seen as British. Mullard (1973) further expressed this view by quoting, A black born in Britain, is a shadow of a man. You are non West Indian, Pakistani or African, because you were born in Britain and you know little or nonhing about your parents coun analyze (cited in 1978,181). Therefore, youth felt somewhat disillusi one and only(a)d to their belonging, subsequently resulting in diaspora and animosity towards whitened inhabitants.Moreover racialised grandiloquence was evidential within society and the me dia. Love thy Neighbour was a popular British sitcom in the 60s which sought to demonstrate prejudicial attitudes towards black people within Britain, which were expressed on a day-after-day basis. It further sought to portray the way in the prejudicial, bigoted attitudes expressions of the character Eddie Booth appeared stupid. On the opposite hand, the black male character Bill Reynolds, was a smart educated person, who much ended up having the last laugh when Eddie tried to outdo him. Rising Damp which also aired in the 1970s had elements of racial discourse from the main character Rigsby, who was the landlord, towards one of the tenants, Philip Smith. As Philip was a black man, he often brought out knee-jerk suspicions from Rigsby. From analysing these television episodes, its seems incontrovertible that these programmes presented a crystallise image of the prejudicial discourse/ neo compound sphere of thought that was poignant within society, however at the same time, it en deavoured to humanise the element of racialism in rear to portray how futile and inane these attitudes were.One cannot negate the element of mugging, which had heightened black youth subcultures. Hall et al. in Policing the Crisis Mugging the State and Law and Order (1978), explained the considerable impact that the media had in perpetuating a negativistic image of black young males, being constructed as your archetypal muggers. This had a pronounced effect within society, causing a moral panic and influencing the police force to carry out more duty tour and searches on black people than their white counterparts. The extent of the excessive stop and searches brought about the West Indian Standing Council to claim that the police were engaging in nigger hunting and that the British black people had now been demonised.Rastafarianism brought collective identity amongst a reduce of black youth. Bound together by their struggles and looking at to their return to Zion from Babylon. T he Rastafarian movement arose in during the 1930s in Jamaica. Rastafarians worship Haile Selassie I, believing he is the resurrected look of Jah and will ultimately lead Rastafarians to Zion (Ethiopia). In order to achieve this, western society (Babylon) is strongly rejected, and seen as corrupt. Rastas also believe in Zion being the original birthplace of mankind, and embrace various socio-political and Afrocentric teachings of Marcus Garvey who is regarded as a prophet. The use of cannabis is embraced, both within spiritual realms and as a symbol of rebellion to Babylon. Rastafarians usually grow their hair into dreadlocks, backed from a Biblical perspective. The Rastafarian colours are red, gold and green, originating from the Marcus Garvey movement, the Jamaican flag, and the Ethiopian flag. In the case of black subculture in Britain, Babylon was identified as London, furthermore Brixton, as in that respect was a high volume of Rastafarians. Dreadlocks were seen by the police in effect as sticking two fingers up at them. There was a deep sense of animosity amongst police and their dislike for black in particular having dreadlocks. It is important to note that although not all black youth espouse the Rastafarian religion, the overwhelming majority of black youth embraced the clothing which they used as symbolic significance to try and end the problem of racism. Rastafarians were often criticised for their beliefs, and in extreme situations, were even rejected by other blacks within Britain. It is imperative to mention that the entitle of fashion Rastafarians adopted, was also embraced by some white males. The clothing style was adopted, and in some cases, selective patois words were used.Reggae played an integral role within Rastafarianism. This symphonyal genre was very distinctive as it drew on vivid experiences of black people in Jamaica. It was further distinctive as it used its proclaim language, being Jamaican patois, which was stolen by thei r master during slavery and colonialism. Usually, the medicament demonstrates the journey from Africa to the West Indies during slavery. Furthermore, reggae sought to express a back to Africa belief, and a vision of a new(a) Africa found on an Arcadian vision (1990,19). Reggae is also known for its critique of Babylon within its lyrics. On the whole, it is clear that Rastafarianism was a religion adopted by black youth, it were a religion symbolising the struggles a deliver the goodsst the white overriding culture in Babylon.Moreover, the event argument Against Racism (RAR), is another example of how ethnic cultures had element that associate to some white youth. The campaign was set up in 1976, and used to be a one off occasion. However this changed when Eric Clapton made a remark which supported Enoch Powells River of Blood speech. This was met with heightened animosity amongst youth of ethnic nonage, and fans in the rock/punk scene. There was further irony as Eric Clapton had been very much influenced by black music, further, teaming up with Bob Marley to create the hit I shot the Sherriff. Carol Grimes, who became a leash spokeswoman for RAR, commented that the campaign was more than tackling the element of race but for anyone who were victims of discrimination because of going against the status quo. She quoted, the whole Rock Against Racism thing did more than just challenge racism it made the idea of black, brown and white united something real, and together we could tell the fascists to f**k off (2009,223). The concert included Rock and seedy fans, of ethnicities. Without hesitation this extract shows that this campaign that punk/rock fans of black ethnic minority adopted within their subculture. Neverthe slight, the concert embraced all people against racism and discrimination.The concept of black youth multitude culture is still present within modern day. However, the reasons for their grouping up is somewhat different to that of the 1960s . As previously scripted earlier, black youth who followed the Rastafarian religion, or just adopted the style of clothing, were regarded as rude gang boys/ black gang rastas. Malcolm W. Klein expressed the view that in recent times, the UK has been typified by a number of gangs generally situated in London, Manchester, Birmingham and Liverpool. Klein further quoted that a resonating feature of these gangs, is that they were predominantly black ethnic minority street members, involved in the sale of drugs with high intergang rivalry and high levels of violence (2001,154). He specifically, looked at two gangs in Manchester, located within impoverished areas, called Moss Side. The name of the two gangs were, Gooch and Doddington, both involved in the drugs trade. Furthermore, they were also characterised by their sheer violence, which peaked in 1992, with no less than 100 shootings taking place. This gives a flavour of the way in which black youth subcultures have changed in present day, with race struggles no longer pervasive, but characterised by the concern of selling drugs and being stern. This concept describes an individual expressing masculinity and effect within the physical realms. Through this, they are subsequently able to acquire status within the gang, and gain a better reputation.Grime genre brings the question of whether black subculture is a distinctive black subculture. Originating in the early 2000s as primarily a growing of UK garage, it started to become more apparent from 2003, when Wiley and Dizzee Rascal released their albums Treddin on Thin Ice and Boy in da Corner respectively. It should be noted that research on this genre of music has been somewhat scarce, and my own overture is that it would bring interesting findings. Grime is now listened to by youth of all ethnicities, of all social classes. For example, Dizzee Rascal and Tinie Tempa have now helped to open the market to those who would not have usually listened. The sound of grime music has evolved, now having a fruity fusion with elements of pop and disco music. However predominantly black working class youth subcultures very much retain grime as their music in which they can re young to, especially during its infancy. During this time, and to an extent now, grime was based upon being hard and getting money. An example being hard is a tune by bawler called Gangsta, which was banned from television. Further interest, is the demographic location of grime videos. When watching Giggs Talking the hardest, the videos is set in Peckham, with a group of working class boys, predominantly black, with some having black bandanas as a sign of trueness to the SN1 crew. The video at times also depicts the struggles that youth are going through, such as their mesh down accommodation. It seems incontrovertible that black subculture in grime is now based upon three elements, which is depicted within grime music, being hard getting money, and gang affiliation through certain dress codes. However, the development of grime has seen a wider market be advent interested, and with it has brought youth of different ethnicities. Asiatic subculture was another example of resistivity that was present during this time. Less research on Asian youth culture was published during the 1950s to 80s. Asian youth subculture will be specifically about Indian, Pakistani and Bangladeshi youth. Asian youth culture took aspects of the parent culture, in particular, the acceptance of the struggles their parents went through, and wanting to fight these problems. From a historical perspective, Asian political struggles were spy in the 1950s and 60s, prior to when Indians and Pakistanis entered the country. Asian political members were located within the realms of left wing politics. Examples being MP Saklatava (MP for Battersea). Rajani Palme Dutt, was another influential communist writer, who lived in London. The first association set up was the Indian Workers Associa tion (IWA) in 1938. It was conceived in order for members to help fund for independence in India. However pastime Indian independence in 1947, the IWA was disbanded. The IWA were setup again in order to provide support for Asians coming to the UK, during mass emigration. Though individuals within the IWA comprised of different left wing parties within India, they sought to work together, not only provide social welfare to migrants emigrating, but to also deal with the problems of racism. Further, the ethos stated their unwavering stead in tackling racism within society, quoting to, fight against all forms of discrimination. promote the cause of friendship, peace and emancipation (p.40).Mike Brake wrote that Asian parents were in control of many aspects of their childrens lives. Females were closely watched by parents and part of the rules were that they were inefficient to go out at night, and due to this, it wasnt unusual for girls to attend daytime raves. Asian parents were un likely to clear of their sons attending multi racial youth organisations, as it was feared that they would fall into bad company and furthermore, different religious and ethnic traditions (1980, 129). Brake commented that for Asian youth, home and school were two distinctive different worlds. Brake further believes that the different worlds gives reason to explain why youths wanted to seek new ways, different from their parent cultures, in order to deal with the racism in society, as the parent culture had failed to do so.By the mid to late 1970s the first generation of Asian youth were confronted by racism within a number of aspects. Furthermore, the youth continued to watch their parents being victims to racism within the employment system, through getting less pay than their white counterparts. Moreover, the 1970s was characterised by the recession that took place. During this time African- Carribeans and Asians were seen as the scapegoat. Nevertheless, looking specifically at the Asian comm unanimity, media reports were published which quoted headlines such as, Asian flood and Asian invasion (2006, 42). Heightened tensions were seen in 1976, when Gurdip Singh Chaggar was killed by racists. To authorise matters worse, the Metropolitan Police Commissioner, Robert Mark commented that the motives for Gurdips death may have not been due to racism. This was met by general outrage within the Asian community, blaming the National Front for the murder. Division was found when the IWA wanted to work through diplomatic channels, to address the problem, however, Asian youths wanted to carry out direct action. Due to this, youth in Southall decided to organise a march, shouting, we shall fight like lions (2006, 42). During the demonstration, they staged a sit in and refused to set forth until two detainees who were part of the demonstrations had been released. This was seen as a watershed moment, as this brought about the emergence of the Southall Youth feat (SY M).What was more intriguing about Asian youth culture, is the way in which they perceived themselves to be politically black within a white society. Although knowing they were not black, as in terms of climb colour, thoroughly felt black as a political position. There was an innate sense of unity in the midst of them and youth of African/ Caribbean origin, as they were experiencing the same struggles and hardships. However, in the eyes of racist white N.F.s, African and Caribbean youth were seen as hard individuals, who could stand up for themselves. However, Asian youth were seen in an obverse light and in consideration of this, Asian youth culture drew on black political movement transatlantic, especially, the sullen Panther group. On the AYM flag, they adopted the black fist to portray an image of collective strength, solidarity and defiance. Therefore black was moulded into a concept of political identity uniting against all forms of racism, further symbolising that racist at titudes should no longer be tolerated or accepted. From this research, it is clear to see that Asian subculture was non secular and non sectarian. It was a culture that embraced all Asian citizens regardless of the country of origin. Resonating with the work of Cohen, Asian youth cultures identified on that point were contradictions within society, so feeling these had to be resolved.Bhangra was a major characteristic of South Asian culture, in that the music displayed a cultural meaning. Bhangra emerged in Britain during the 1950s. The south Asian population brought a distinctive heritage which was seen in their music. The 1970s was a particularly important time within the transition of Bhangra music. During this time a BBC TV Asian program called Naya Zindagi, Neya Jeevan shifted the emphasis of their series to South Asian British groups and artists. Alaap was a group from Southall who were often played on the show. Their music brought a distinctive fashion to bhangra, fusing bh angra with elements of disco music, known as the Southall twist. On examination of the research, I would take the view that the transition demonstrated Cohens work on the relationship between the parent and youth subculture. The first generation of Asian youth within Britain never had the same get together with South Asia as their parents had, so they altered the style of bhangra music in order to create their own meaning for themselves. This new form of bhangra had distinct values and meanings for Asian youth in Britain. As result of its commercialisation, some have drawn parallels with grime and reggae music, in the way in which its lost its distinctiveness as a purely distinctive Asian youth culture. In recent times, there have been a increase in the amount of songs which have elements of bhangra and hip pop flavours which have been released. Examples of these are Punjabi MC- Knight rider Bhangra, and Jay Sean Ride it. My own approach is that similarly to comments on reggae, al though bhangra has now been commercialised, one would still identify as a distinctive, as when one listens to the music, one identifies to a specific ethnic group of people.Upon reflection, ethnic youth subcultures have had profound effect within British society. Since post emigration of ethnic minorities from the Commonwealth, Britain have witnessed distinctive ethnic cultures emerging. Rooting from the growing racism and discrimination, happening through a number of avenues. Parent culture somewhat influenced youth subcultures. However, in line with Cohens theory, both Africa/ Caribbean and Asian youth, felt that parent subcultures had not dealt with the problems they were facing, thus having to create new subcultures to solve the contradictions. Although there are some who question the distinctiveness of the subcultures, my own approach is that, in essence ethnic subcultures were created as a way to create identity and meaning through confidence, unity and self realisation, but a t the same time defy against racism. Nevertheless, certain elements have been adopted by youth of different ethnicities, such as Rastafarian dress and the listening of bhangra. Although saying this, there have been plausible evidence to demonstrate that black subculture has lost its distinctiveness, now adopting social class reasoning. smell at certain grime songs and gangs in urban areas, there has now been the notion of being hard and getting money. The youth have been overwhelmingly working class and have embraced those of different ethnicities, who are in the same social position, struggling against the class system, rather than being in Babylon.
Thursday, April 4, 2019
Information Security Management and Purpose
data pledge Management and PurposeInformation SecurityThe success and competitiveness of individually business in the market is highly dependent on its infrastructural ability to protect its valuable assets from the rivals and otherwise competitors. It was the old days when the resources and assets of organizations were materialistic which in now a day deplete turned into reckoner programs and files that have the training related to corporate secrets, trades, agreements, figures, values and formulas, randomness ab by markets, customers and sales on with pecuniary statements and economic status. All this confidential data should be protected and this is where the field of information security go in. information security in itself is quite a diverse term that incorporate the diametric strategies and uses the computer programming and sophisticated softwares to protect the important information from getting into the access of wrong hands (IAPS, 2015).The master(prenomina l) purpose behind the process of information is to make the systems, information or data less indefensible to the external threats by violation of legal and corporate rules eon alike to maintain the integrity of the organization. in that respect are different forms of the information security formed, tested and installed based on business and kind of information like detection of any threat or breach into the companys online database or computer files, encryption of the data into an unreadable form, checks of the already existing infrastructure to determine its ability to keep the data protected. Other than that, at the perplexity and administrative level information security corresponds to the implementation of the rules that must be properly g everyplacened and followed by each and every individual in the organizations. As a whole the information security deals with the instruction of corporate data, vulnerability measurement, could computing, data protection and security of specific programs (ISACA, 2017).Job 1 Information Security Program ManagerThis is a management level gambol at the organization where the selected candidate entrust be responsible for overlooking and coordinating with the technical teams and programmers to make sure that all the requirement of the lymph node and customers are being met and completely understood. The job requires the absolute time management skills, leadership attributes including eh abilities to meet the guidelines and carrying out all the tasks efficiently. This jobs requires the strong command and knowledge of the information security protocols, concepts and terminologies. The company deal in the 6 major sectors of the information security including the vulnerability management, monitoring, adoption, access and identity, governance and training. The job requires the degree in the management of information security along with computer sciences with the strong knowledge of the security and risk assessment alon g with the technical tantrums related with the information technology and the excellent communication and presentation skill with verbal and write information sharing. This job is entitled to provide a great opportunity for growth and career instruction in the field information security by also achieving the business dynamics in a diversified way because of the thickenings in different sectors (SP Global, 2017).Job 2 Information Systems OfficerThis job is stick on by the office of United Nations for the position of the information systems incumbent in their office in bleak York which is currently open for the application related to the field of the information systems and security. This job posting covers another aspect of the information systems in an organization where the hired candidate would look after the management of integrated information systems, dealing with the customer management, automation of the different functions, implementation of the new softwares and prog rams to achieve better performance and outcomes. The officer would be responsible for the complete documentation of the information systems in terms of their specifications and requirements. The officer will also take care of the access to the proprietary data and identification of the different individuals for granting access along with the maturation of new security programs and would create the software platforms for the integration of the existing functions that are kind of related to each other. Along with the testing of information systems the coordination and communication between the organization and clients would be included in the job responsibilities as well. The basic and important qualifications for the job include the in-depth knowledge and understanding of the information systems, security and management, digest of the existing infrastructure and databases (United Nations, 2017).Job 3 Information Security Systems OfficerThis job requires an individual with a strong background in the information systems and their security having an experience of the verification and testing of the security systems tally to the rules and regulations implemented by the federal authorities. The responsibilities would include updating the existing infrastructure of data processing match to new certifications and affiliations in the complete context/ strong coordination with the information security manager would be undeniable throughout the time. Security of the applications while making sure that follow the procedure, specifications and guidelines of the client and policies. Degree in information technology along with the risk assessment skills along with customer satisfaction, security planning and grip over effective documentation of all the software systems is required.Pervasive Technologies and Information SecurityPervasive technologies come as an integral outcome of the wireless networking among different mediums, internet and internet of things, embedded systems and artificial intelligence where different modules function and interact with each other through sharing of information. The environment around us is wax of the pervasive technologies where the most important or significant ones include the surveillance systems, monitoring and control systems, encroachment or theft detection within a facility or computer system. All these abstruse networks of devices should be protected from the external threat that can break in and be a strong reason for increased threats and vulnerabilities.As the information security deals with the protection of different computer, software and IT systems pervasive technologies have a strong link with it. The sensors and different kind of tools and machines used in pervasive technologies must circumstances the correct data and information without being altered or delayed and there comes the role of information systems where the testing, updating and verification of the infrastructure is to be done in order to meet the specification of the client and customers because the growth and success of their business depends on the extent to which they are reluctant to share the confidential information. get an understanding of the pervasive technologies in ways of the interaction between different devices and protocol I would be achieve the skills of analyzing the competency or ability of the security systems to avoid any external violation while the improvement and new methods for the data processing would be implemented in the pervasive technology in order to make them more efficient and reliable.ReferencesIAPS. (2015). Information Security Overview. Retrieved from www.iaps.com http//www.iaps.com/security-overview.htmlISACA. (2017). Information Security Management. Retrieved from www.isaca.org http//www.isaca.org/Groups/Professional-English/information-secuirty-management/Pages/Overview.aspxSP Global. (2017, march 3). Information Security Program Manager. Retrieved from careers.spglob al.com http//careers.spglobal.com/ShowJob/Id/1131125/Information-Security-Program-Manager/United Nations. (2017, February 10). Information Systems Officer, P3. Retrieved from careers.un.org https//careers.un.org/lbw/jobdetail.aspx?id=73254
Womens Rights in the 20th Century
Womens Rights in the twentieth CenturyThroughout the history of the human race, women have been chastised, degraded and completely controlled by their anthropoid counterparts. Women have been oppressed and controlled without whatever room for retaliation. Whether it be an over-bearing father or an abusive husband, women had barely any say in what happened to them. They were housewives and child-bearers eldest and human beings second. Only during the 20th century did women make the most wide progressions towards sexual urge equating. Opportunities arose and women seized them, grasped for them and utilise them to their full potential. Inter-related events throughout the 20th century allowed women to progress and they provided the necessary pushes towards gender equality. The women of the 20th century are responsible for the rise of gender equality in Canada The affair of women in realism war one (WW1), the Persons Case and the Famous five the first-class honours degree twin e of feminist movement were important crook shews in the beginning of the century as sound as the roles of women in cosmos contend 2, their changing roles, and the actions of Agnes MacPhail which all lead to the second turn over of feminism that instigated the alteration of the pack of Rights and Freedoms.The beginning of the century was extremely important to the proclamation of gender Equality. It introduced Women as important figures in society and that they could make as a lot of a contribution to the world as men. Women participated in knowledge domain War 1 and helped with the war driving they combated womens rights on a legal scale for the first time via the Persons Case and sparked the first wave of feminism. Women secure socks and attire for the men in the war and prevented them from suffering from diseases such as trench foot and they provided silver for the war effort as well as took care of the children back at home many women even imprinted in factories to make sure the economy was stable in Canada. In fact, by 1914, about 20% of the workforce was female (Hundey and Margarry, 45). Almost 2400 nurses worked near the horrific battlefields in World War 1 and provided aid for the injured men (Santor, 36). These were important contributions because they gave women a base to fight with they showed their capability and that they were not bemused individuals. This displayed that women could make just as much contributions to the world as men. Robert Bordens promise to allow women to vote aft(prenominal) the war was important in scooping the first wave of feminism because women could now vote. It allowed them to make a legitimate say in what occurred in the government by voting who becomes the leader of the government. In the beginning, it just now permitted them to vote if they had husbands in the war or if they were alive(p) in the war by being nurses. This at last escalated to them being able to vote without complications which sparked the first wave of feminism. The first wave of feminism included the flapper straw man which emancipated them from the bonds of traditional womanhood through the scandalous clothing and makeup (Hundey and Margarry, 118-119) also the previous events of World War 1 had more women going into the workforce. Women no longer had to have husbands to be self-sustainable, independent women. Unfortunately, women did not earn as much as men and at the end of World War 1 were expected to step down from their jobs for men (Hundey and Margarry, 45). Regardless, some women proved that they were sufficient and even fought for womens rights more intensively. The first step into legal battles against gender equality was initiated by the famous five through the Persons Case. Famous women the give cares of Emily Murphy and Nellie Mclung petitioned and fought a legal battle to have women be considered as qualified persons recognizing their right to nurture and work, relinquishing them of thei r ambiguous person status (Historica). This was a springy step in setting up the stage for the Charter of Rights because it recognized women as legitimate members of society. Women tried hard to promote gender equality and it paid off. The efforts of the women in the beginning of the 20th century were the women who would be the initial instigators of the re-evaluation of the Charter of Rights and freedoms.At the start of World War 2 women had a chance to portray themselves as the useful and needed members they were of Canadian society. f They were not incapable second-class citizens. Women throughout the 1930s and World War 2(WW2) participated in World War 2, changed the role of women and portrayed their commitment to politics through Agnes MacPhail. Women played a pivotal role in World War 2 because the participated in directing planes in the RAF as well as cooking, cleaning and supporting the men in military bases, over 46,000 Canadian women were enrolled in military work (Hunde y and Margarry, 221-222). On the home front, everyone relied on women to work and to take care of their children. Many women took care of the children back at home and worked in factories in order to provide munitions for the military, by 1944 1 million Canadian women were in the Canadian workforce (Hundey and Margarry, 221-222). Unfortunately, it seems like women made no advancement in the public mind because mountain still expected women to drop their jobs for men when they came back from the war but even so women kept fighting (Hundey and Margarry, 223). However, just like in WW1, it continued to give women a base to fight with. They used their participation to accentuate their contributions and once again to prove that they should not be enslaved to lives as housewives and child-bearers. By participating in WW2, women proved their worth once again and they had sewn the seeds for a new wave of feminism (Hundey and Margarry, 223). Women utmostly began to challenge their roles i n society and began going into higher level careers as well as entering into politics, they had begun developing more community organizations and services for women (Hundey and Margarry, 223 Anderson). The Role of women was changing throughout World War 2 and they were slowly becoming accepted participants of the workforce. Although their wages were still minimal they were presenting themselves as a capable minority that was beginning to work in professions such as Medicine and Law. Agnes Macphail was the first female senator and the first woman with a political position in Canada. Although her term was short, she made contributions to feminist movements by continuously writing articles and performing at speeches (Hundey and Margarry, 129-130, Doris Anderson). Although she did not actively participate in womans suffrage she was good friends with suffragists like Nellie McLung and was a role model for women all throughout Canada (Anderson). By the mid 1940s, women were still fightin g for gender equality they did not forsake the efforts of the women who strived before them and instead built upon the efforts of those who had started the surge of gender equality.The second wave of feminism was an international surge of all women in the world that promoted gender equality. By the 1960s women were provide up with their conditions, they felt like they were treated as second class citizens because wages were going up, unemployment range were going down, but women were still considered lesser to men (Bellamy, Liz, and Kate Moorse, 73) and therefore started the second wave of feminism or the Womens Liberation Movement (Hundey and Margarry, 277-278). Women finally had the resources to strongly campaign for gender equality they had the media, television, radio as well as constantly increasing literacy and education rates for women (Bellamy, Liz, and Kate Moorse, 73). The second wave of feminism would be the final push needed to seal the deal with gender equality. In re sponse, the Royal Commission on the term of Women was created in order to recommend steps towards womens equality (Hundey and Margarry, 341) and was important because it gave a layout as to how the Charter of Rights and freedoms would be altered in the upcoming years. The Royal Commission made sure that in the 1970s homophobic employment on the basis of gender was illegal and it gave recommendations towards how gender equality would be achieved (Anderson). All of these events, in conjunction were crucial in battling the government to change the Charter of Rights and Freedoms. By the 1980s women were still prevent because they were not considered equal, even though 45% of the workforce was female at this point, women solitary(prenominal) earned 72% of what men earned (Colyer et al. 32) it was evident that the RCAW was not helping and it was time for a change. It was a turning point in the century because the constitution was the highest law in Canada and no government was allowed to violate it to the point where a government that did could be struck down (Colyer et al., 377) and in 1982 the constitution was finally changed to include sex in the following passage Every individual is equal before and under the law without discrimination establish on race, national or ethnic origin, colour, religion, sex, age or mental or physical disability.(Canadian Charter of Rights and Freedoms, Section 151). Women had finally achieved what they rightly deserved. Their intense lobbying managed to push the government to change the Charter of Rights and Freedoms which was considered the highest law in Canada, it was a pivotal moment for women but it could not have been achieved without the struggles antecedent to it. The Charter of Rights and Freedoms made sure that women had completely equal rights in all aspects and any violation of it could be challenged in court as an offense towards human rights. Women had succeeded in triumphing over the gender boundary that had kept them chained for millennia. They put a stop to the battle of the sexes and legally introduced gender equality through the Canadian charter of Rights and freedoms, the most vital document in the history of gender equality.In conclusion, the women of the 20th century and their actions were indubitably the prime forces in the rise of gender equality. The 20th century was the turning point for how women would live their lives. It is sad to imagine that prior to the 20th century women were confined to being wives, child-bearers and basically objects for a mans desires. This has all changed thanks to the efforts of women through all the events that occurred. The role of women in World War 1, the first wave of feminism and the Persons Case as well as the role of women in World War 2, Agnes Macphail and the changing role of women were all events that set the playing field and boosted the status of women in society to have the required edge to begin the second wave of feminism that would le ad to the Charter of Rights being changed once and for all. Through all of time women were oppressed, manipulated and used and it is only now that they finally get the opportunity to flourish and succeed in an equal and fair country, Canada. Nonetheless, women had to work hard and fight for their right to be considered equal Roseanne Barr once said that, The thing women have even to learn is nobody gives you power. You just take it.
Wednesday, April 3, 2019
Westgate Bridge Collapse Engineering
Westgate duo soften EngineeringThe West adit Bridge fell down on the 15th of October in 1970, it was caused by a few half girders on the west part of the bridge that didnt fit. They attempted to fix this with an unusual manner which make the situation worse. The bridge claspd and eventually collapsed. It killed the workers while they were on ease up and only a few were left alive.IntroductionThe West Gate Bridge started construction in 1968 and was the second interminable bridge in Australia. The building process was going well at first though an unusual method was being used throughout the project. About 2 years into construction, problems began to show. There was an imbalance between several steel girders which made them non fix into position. Some engineers proposed putting 10 concrete blocks which weighed 8 tons individually, on each of the girders to put them into place which caused the bridge to buckle. screen backgroundThe company Freeman Fox Partners was in charge of build and this was their twentieth bridge.Some of their previous works were The Adome Bridge, Humber Bridge, Erskine Bridge, and Forth Road Bridge. The West Gate Bridge is a cable-stayed bridge in Melbourne, Victoria, Australia which hybridizened over the Yarra River north of Port Phillip and is an chief(prenominal) link to the inner city.InvestigationFor the most part, the investigation was mostly interviewing survivors and explaining what happened. The inculpation was mostly on the engineer who designed it and the engineers who ordered the concrete blocks.FindingsIt was put up that Ward, aka Freeman Fox Partners were responsible for giving the designs.The bridge was built jaggedly and they tried to put concrete blocks on the girders. Their measurements were fixed in the redo and there were no problems during the process.ConclusionIt was structural engineer fault delinquent to the failure of measuring properly and allowing to fixing the problem with concrete bricks, which resulted in the bridge buckling. The mess was cleaned up almost immediately. The ambulance got the wound, the bring upfighters put out the fire and the construction crew cleaned up the wreckage and started over. The bridge was reopened to the public in 1978.NotesCamber- is a rate of elevation between two railsSnapped after removing buckleStructural design failureFreeman Fox PartnersSecond longest bridge in Australia and highest in the countryIn October 15 1970, The span between piers 10 and 11 collapsed2,000 Tonne mass plummeted into mud and created an plosionRescuers risked their livesGirders are large iron or steel beams used in complex structuresUnusual method of construction35 killed, 18 injuredKnown for jumpersSteel box girder cable-stayed bridgeBegan construction in 1965A cable-stayed bridge has one or more towers from which cables support the bridge deck of cardsSourceshttps//www.google.com/culturalinstitute/beta/exhibit/wQLmdTVt https//en.wikipedia.org/wiki/West_Gate_Bri dgehttp//webcache.googleuser capacitance.com/search?q=cacheUccIiYplRh8Janengineersaspect.blogspot.com/2009/10/west-gate-bridge-collapse-on-its-39th.html+cd=2hl=enct=clnkgl=ushttps//qph.ec.quoracdn.net/main-qimg-f4416355b6576128ede23ea6abd5452e-c?convert_to_webp=trueRubric rating submitted on 12/21/2016, 122028 PM by emailprotected1050Title PageYour attain 5x giftnot makeTable of ContentsYour come to 5xPresentnot doneAbstractYour score 10Presentnot doneIntroductionYour score 5xBackgroundYour score 5Presentnot doneInvestigationYour score 5Presentnot doneFindingsYour score 5Presentnot doneImpactYour score 5Presentnot doneConclusionYour score 5xnot doneReferencesYour score 10References includedno referencesNotesYour score 10Notes recordedno notes6 Content PagesYour scorefilled 6 pages3 content pagesno contents pages
Tuesday, April 2, 2019
Greek and Roman Sports
classic and roman Sports antiquated Hellenic and Roman civilization make up made many contributions to westerly civilization. Especially when it comes to politics, trade, and sports. From wrestling to javelin, ancient sports set the pace for some of the sports we see in our day and age, especially the exceeding Games. In old-fashioned Grecian and Romans sports, athletes contested very hard and it was a public display that was a trait of the religious and social life of ancient Greece and Rome (Osborne 15). Ancient athletes trained and participated for physical exercise, competition, and to honor their gods. In this paper I go away discuss the Greek and Roman attitudes toward sports.The ancient competition, physically, was relatively different from the sportsmanlike events we have now a days. There were far fewer events and alone free Greek men (and sometimes boys) were allowed to compete because of the barbaricity. Also, there werent any team sports every sport was one ma n against other/others, because they were more concerned about individual merit. Some of the different sports the Greeks participated in where javelin, running (with and without armor), and discuss. Moreover, some of the more brutal sports they embarked on where wrestling, boxing, and pankration (a form of wrestling and boxing). Some of the games where brutal and you had to participate naked, but it intend on showing the beauty of the tender body. The four main cycles of games were the Olympic Games, the Pythian Games, the Isthmian Games, and the Nemean Games (Kyle 48).Romans on the other hand based their sports around unpeaceful displays, most notably the fights amongst gladiators. They included a gladiatorial combat, stage-plays, chariot races, acrobatic competitions, and a mock naval battle. Without a inquiry, the Greek games depended for their entertainment think of primarily on rivalry among athletes while the Roman games were often string by the staging of battles fough t to the death and involved large numbers of human beings and also beasts (Kyle 184). The Roman sporting events I think were more brutal especially when it comes to the fights amongst gladiators when most of the time they fought to their death. While on the other hand, the Greeks were involved with the sports and the Romans simply watched them and cheered for the participant they cherished to win.In conclusion, the Greek and Roman sports helped create some of the sporting events we have today and definitely started athletic competition. We can clearly see the making love for sports in Greek and the Romans. We learn that the ancient Greeks and Romans shaped their own vagary about the meaning of life. The Roman games were radically different from the Greek games in several respects. However, their sports show the mindset of the people of that time. The Greeks were more interested in showing off the human body while the Romans were more inclined on massacring the human body. I think this shows that compared to the Romans, the Greeks valued human life more. Without a doubt modern Americans would find much of these sports awfully violent particularly the hundreds of gladiator fights and animal fights, with their many public deaths of both people and animals.Works CitedOsborne, redbreast Studies in Ancient Greek and Roman Society. New York Cambridge University Press, 2004.Kyle, Donald G. Sport and Spectacle in the Ancient World. New York Blackwell Pub, 2007.
Inroduction To Companies Etisalat Lanka Business Essay
Inroduction To Companies Etisalat Lanka Business EssayAs a consultant of baksheeshing management consultancy I am going to do a brief research on the disposals and behavior section. To do this subsidisation I have selected 2 companies in the telecommunication industry. One is Etisalat Lanka PVT LTD which is base in Abu Dhabi and operating in 18 countries including Sri Lanka and second partnership is Lanka buzzer Services PVT LTD which is operated only if in Sri Lanka. So in this assignment I am going to discuss briefly in their arrangements expression and nuance beas, and also I am going to discuss active the catamenia leadership styles of the companies.INRODUCTION TO COMPANIESEtisalat Lanka (PVT)(LTD)Sri Lankas first gear Cellular net plant, then called Celltel inaugurated its operations in 1989. A brand name change was d hotshot on the twenty-fifth of January 2007 and on that blameafter named Tigo and this was transformed with Milicom disposing its Asian operations . They atomic number 18 now a company amply owned and operated by the giant Emirates Telecommunication Corporation in UAE. It has across-the-board operations to Asian markets much(prenominal) as India, Pakistan, Afghanistan, Indonesia and now Sri Lanka, recording oer 100 million subscribers across 18 countries offering opportunities for synergy with their former(a) operations in the region. Etisalat officially commenced its operations in Sri Lanka on the 25th of February 2010.Lanka chime confineLanka buzzer is a telecommunication operator that provides skillful range of telecommunication service to business and residential customers in Sri Lanka. With the novel introduction revolutionary low cost CDMA (Code Division Multiple Access) technology, Lanka campana continues to expand its robust modern digital network that currently specializes in internet, data and voice services. Lanka Bell was formed in 1997 as the superstar largest BOI Company in Sri Lanka. It was subsequen tly acquired by the privately held diversified garner Milford Holdings (Private) Limited in 2005. Lanka Bell rebrinys firmly rooted in Sri Lanka as a telecommunications giant that continues to challenge the industry through its uncommon portfolio of services.SECTION 01The organizations expression and conclusion Lanka Bell and EtisalatEtisalat and Lanka bell twain ar running in the telecommunication industry so most of the component parts in the finale and anatomical structure be same. They both are victimization serviceable organizational structure1.1 geo logical formation structure of Lanka Bell Services (PVT) (LTD) pay coachgross revenueMarkt.Board of film directorsChairmanManaging DirectorCustomer Service Depart. skillful Mang.HR AdminGM Technical OperationAssistant manager old managerGeneral Manager -HRMarketing managerBusiness compendManager HRManager- Revenue AssuranceDGM control /MISArea Sales ManagersSales ExecutivesHR AssistantsBilling module DirectorInt ernal comptroller DirectorManager- credit control DirectorSenior service executives DirectorTrainerGM IT team upsAssociates clericalSupervisors DirectorCustomer care Executives DirectorInternal accountant DirectorBilling staff DirectorOrganization structure of Etisalat Lanka (PVT) (LTD)1.3 Organizations culture at Lanka bell and EtisalatThere are many anformer(a)(prenominal) definitions for organizational culture but a popular and simple way of defining culture is how things are done around here A more than detailed definition is The collection of traditions, values, policies, depressions, and attitudes that constitute a pervasive context for everything we do and think in an organization (Atkinson)There are four g types of culture such as Power culture, exercise culture, Task culture and person culture. As both companies are in the telecommunication industry and also both companies are larger companies in Sri Lanka they are following the Role culture.What is Role Culture?Ro le culture stereotyped as a bureaucracy and works by logic and rationality. Role culture rests on the strength of strong organizational pillars the functions of specialists in, for e.g. finance, acquire and production. The work of, and interaction between the pillars is controlled by procedures and rules and coordinated by the pediment of higher-ranking managers. Role or meditate interpretation is more burning(prenominal) than the exclusive and position is the of import source of power.(Laurie J. Mullins 8th edition)So role culture is Common in most organizations today. In a role culture, organizations are split into various functions and each individual in spite of appearance the function is appoint a particular role. The role culture has the benefit of specialization. Employees focus on their particular role as assigned to them by their job description and this should ontogenesis productivity for the company. This culture is quite logical to organize in a large organiza tion.Different dimensions of organizations culture in Etisalat and Lanka Bell winnings tasteIn Etisalat and Lanka Bell profit penchant is law because their main target is to give a best service to their customers, they are concerning chanceing on customer mirth and delight lot OrientationPeople orientation is high in Etisalat because they are paying high hire to their staffs and they are also paying special incentives according to their performance, their operative milieu is very pleasant, they are organizing get to gather parties and motifal programs for their employees but in Lanka Bell People orientation is Law.Team OrientationTeam Orientation is high in Etisalat because its employees prefer to work in multitudes rather in individuals to achieve their sales targets. So team orientation leave lead the company to increase their sales. But in Lanka Bell team orientation is Low where their employees are prefer to work as individuals asylumInnovation is high in Etisalat the y are coming with impertinently products quickly, they starts with prepaid contact, after that came with postpaid, launched 3G, broadband and they are going to launch Etisalat TV. But in Lanka Bell it is very low they are rely only in CDMA connection missionary station statement of Etisalat Lanka PVT LTDTo extend mints reach. At Etisalat, we are actively evolution advanced networks that impart enable people to develop, to learn and to grow deal statement of Etisalat Lanka PVT LTDA world where people reach is not limited by matter or distance. People will effortlessly sound around the world, staying in touch with family, qualification forward-looking friends as they go, as well as developing new avocations. Businesses of all sizes, no long-acting limited by distance, will be able to reach new markets. Innovative technologies will open up fresh opportunities across the globe, allowing the contribute of new goods and services to everyone who destinys them.Vision statement of Lanka BellBe Sri Lankas atomic number 61 next generation communication Information Technology solutions providerMission statement of Lanka BellTo provide innovative next generation scientific solutions by identifying and meeting customer necessitate better than any early(a) industry player, while maximizing the offset of our business for the benefit if our stakeholdersImpacts and relationships of two companies through their structure and culturePerformance for two companies through their structure and cultureHow organizational theories underpins the practice of managementThe contrastive undertakees used by the management of both companiesThere many go upes used by the both companies those are Human relations approachSystems approachContingency approachHuman Relations approachThe main emphasis of the classical writers was on structure and the formal organization, but during the 1920,s the years of the great depression, great prudence began to be paid to the social fact ors at work and to the behavior of employees inwardly an organization that is, to gentleman relations.Human relations approach Emphasized vastness of human attitudes, values and relationships for the efficient and effective functioning of work organizations.Systems approachThe classical approach emphasized the technical requirement of the organizations and its strikes-organizations without people the human relations approaches emphasized the psychological and social aspects, and the consideration of human- postulate- people without organizations circumspection is focus on the total work organization and the inter relationships of structure and behavior.Productivity is viewed as a function of the interplay among people, structure, and the surround.The organization is a hard social and technical open system that requires human, financial, and material resources.Contributions of Systems Approach To heed-Under systems approach, managers have a good view of the organization.It gi ves importance to mutualness of the different parts of an organization and its environment.It foretastes consequences and plans actions.A system thinking warns managers against adopting in stages approach to the problem- lickContingency ApproachThe contingency approach to organization demonstrable as a reaction to the idea that in that location are general principles for designing organizations, motivating staff etc. newer research suggested that different forms of organizational structure could be equally successful.(Class Notes)The contingency approach, which roll in the hay be seen as an extension of the systems approach, highlights possible means of differentiating among alternative forms of the organization structures and systems of management.(Laurie J. Mullins 8th edition)The organizations structure must be matched to its environment to enhance performance.The optimal form of an organization is contingent on the circumstances organizationd by that organization including patients, third-party payers, regulators, and personnel. class 02Different leadership styles that Etisalat and Lanka Bell are followingDefinition leading style is the way in which the functions of leadership are carried out, the way in which typically behaves towards members of the group.Both companies are using the Democratic style, and Laissez- faire (Genuine) style because of market growth and due to the size of the company, for which the autocratic style is not desirable to follow in the telecommunication industry.Democratic style is where the focus is more with the group as a whole, and on that point is greater interaction within the group. The leader ship functions are shared with the members of the group and the manager is more part of a team.Laissez- faire (Genuine) style is where the manager observes that members of the group are working well on their own. The manager consciously makes a decision to pass the focus of power to members, to allow them freedom of action to do as they think best, and not to interfere but is readily available if ease is posited. There is often confusion over the style of leadership behavior. abstract of different leadership styles and their effectivenessThe democratic leader works with the group to help members to come to their own decisions, the Laissez- faire leader leaves the group alone to do whatever it wants. Both styles are good for both the companies, because there are number of teams, and departments, in both companies.Therefore the democratic style will suite certain departments and teams, when there is a situation where the team members are unable to make a good decision, compared to the Laissez- faire style which will be applicable to departments and teams who are able to make effective decisions rather than relying on the managers decisions.Effectiveness of Democratic StyleRisk is low. Managers have experience in making effective decisions therefore this reduces the risk of making bad or wrong choices.If the ideas are going to be open for everyone, then everyone ask to feel comfortable enough to put their ideas on the table. So there are lots of ideas will generatedIt takes advantage of the knowledge and expertise of individuals in different areas, for high quality, flexible decision making.Keeps staff informed or so everything that affects their work and shares decision making and problem solving responsibilities.Staff equals the place they receive and respond with cooperation, team spirit, and high morale increasing.Develops plans to help staff evaluate their own performance.Allows staff to establish goalsEncourages staff to grow on the job and be promotedEffectiveness of Laissez- faire (Genuine) styleThe manager provides little or no direction and gives staff as much freedom as possible so it motivates employees.In the telecommunication sector there are lots of sales team so, those teams can do their own works to achieve their own goals, this will increase the salesAll pron ouncement or power given to the staff and they determine goals, make decisions, and solve problems on their own.Employees are involved in decisions. This encourages need through greater interest and involvement so new ideas are generated.The free direct approach can prove an effective type of leadership when the team has achieved identity and cohesion, resulting in motivated and resourceful team members. In such situations, the sharing of authority and minimal direction empowers team members.Impact that different leadership styles may have on motivation of employees of Etislat and Lanka Bell when they face the technological breakthroughWhen there is a technological breakthrough that has taken place last week affecting the companies, and the industry as whole, a democratic style leader could consider the following actions to motivate the employeesIntroducing the main goal of the given projectEncourage team members to communicate openly, candidly and continuouslyMembers should b e made aware of the companys economical structure and growth to help them think and affirm ideas that are more applicable to the company. pose a brainstorming session to collect new ideas to compete with the breakthrough.The ideas still through the brainstorming session have to go through the new product development process in order to face the new technological breakthrough.Increasing the working hours, and pay the employees more for working overtime.Should produce special incentives according to their performanceSECTION 033.1 DIFFERENT MOTIVATIONAL THEORIES FOR LANKA doorbellMaslows hierarchy of need surmisalA useful starting point is the work of Maslow and his opening of individual development and motivation published to begin with in 1943. Maslows basic preposition is that people wanting beings. They always want more, and what they want depends on what they already have. He suggests that human needs are logical in a series of levels, a hierarchy of importance. (Mullins, pg 257, 8th Ed. 2007).In this motivation hypothesis Maslow has identified the human needs in five dollar bill main levels. From at the lowest level physiological needs, through synthetic rubber needs, love needs and esteem needs, to the need for self-actualization.450px-Maslows_Hierarchy_of_Needs.svg.pngImage 01. Maslows hierarchy of need modelHerzbergs two-factor theoryThe Two-factor theory (also known asHerzbergs motivation-hygiene theoryandDual-Factor speculation) states that there are certain factors in theworkplacethat causejob satisfaction, while a separate set of factors cause dissatisfaction.Herzbergs original study consisted of interviews with 203 accounts and engineers, elect because of their growing importance in the business world from different industries in the Pittsburgh area of America. He used the critical incident method. Subjects were asked to relate quantify when they felt exceptionally good or exceptionally bad close their present job or any previous jobs, t hey were asked to give reasons and a description of the sequence of events giving rise to that feeling. Responses to the interviews were generally consistent and revealed that there were two different sets of factors affecting motivation and work. This led to the two-factor theory of motivation and job satisfaction. (Mullins, pg 261, 8th Ed. 2007).images.jpgVrooms anticipation theoryThe model of motivation of Vrooms expectancy theory, particularly as it was extended by Porter and Lawler and supplemented by several(prenominal) other theories. Expectancy theory is a broad theory of motivation that attempts to explain the determinants of workplace attitudes and behaviors. The three major concepts underline expectancy theory are those of Valence, Instrumentality and Expectancy, which form VIE theory.ValanceValance is a measure of the attraction a given outcome holds for an individual, or the satisfaction the person anticipates receiving from a particular outcome.InstrumentalityInstrume ntality is a persons belief close to the relationship between performing an action and experiencing an outcome. Determining peoples instrumentalities is important because their desire to perform a particular action is likely to be strong only when both valance and instrumentality are perceived as acceptably high.ExpectancyExpectancies are beliefs regarding the link between making an effort and actually performing well whereas knowledge about valances and instrumentalities tells us what an individual wants to do. We cannot know what the individual will try to do without versed the persons expectancies.ConclusionExpectancy theory thus defines motivation in footing of desire and effort whereby the achievement of desired outcomes results from the interaction of valances, instrumentalities, and expectancies. Desire comes about only when both valance and instrumentality are high, and effort comes about only when all three are high. 4. Theory X and Theory Y of Douglas McGregorMcGregor, in his book The Human side of Enterprise states that people inside the organization can be managed in two ways. The first is basically negative, which falls under the category X and the other is basically confident(p), which falls under the category Y. After viewing the way in which the manager dealt with employees, McGregor concluded that a managers view of the nature of human beings is baseUnder the assumptions of theory XEmployees inherently do not like work and whenever possible, will attempt to avoid it.Because employees dislike work, they have to be forced, coerced or threatened with punishment to achieve goals.Employees avoid responsibilities and do not work fill formal directions are issued.Most workers place a greater importance on security over all other factors and display little ambition.In contrast under the assumptions of theory YPhysical and mental effort at work is as inborn as rest or play.People do exercise possession and self-direction and if they are committ ed to those goals.Average human beings are will to take responsibility and exercise imagination, ingenuity and creativity in solving the problems of the organization.That the way the things are organized, the average human beings brainpower is only partially used.On analysis of the assumptions it can be detected that theory X assumes that lower-order needs dominate individuals and theory Y assumes that higher-order needs dominate individuals.An organization that is run on Theory X lines tends to be authoritarian in nature, the word authoritarian suggests such ideas as the power to enforce faithfulness and the right to command. In contrast Theory Y organizations can be described as participative, where the aims of the organization and of the individuals in it are integrated individuals can achieve their own goals best by directing their efforts towards the success of the organization. However, this theory has been criticized widely for generalization of work and human behavior.SUITA BLE MOTIVATIONAL opening FOR MANGERS AT LANKA BELLFrom the theories mentioned above it is understandable that managers need to pick one or two theories that are more applicable for their own company to work more effectively and generate higher numbers of positive outcomes Therefore based on this assignment manager of Lanka bell needs to pick out a suitable motivational theory in order to run the company with great success. Understanding the needs of Lanka bell it would be advisable that the manager should initially pick Herzbergs two-factor theory due to the following reasons.Why Herzbergs two-factor theory is important? And effectiveness of using Herzbergs two-factor theoryHerzberg (1968) saw two basic needs of individuals, and he suggests two factors.The need to avoid unpleasantness, satisfied (temporarily, and in a rather negative way) by environmental factorsThe need for personal growth, satisfied at work only by motivating factorsEnvironmental Factor or Hygiene factorIn this f actor Herzberg has explained about the working environment which is company policy and administration, Salary and job security, in this factor he mentioned the main needs of the employers.Motivator factorMotivator factors, on the other hand, create job satisfaction and can motivate an individual to superior performance and effort. These factors satisfy the individuals higher need for a sense of self-actualization or personal growth, and intromitStatusAdvancementGaining recognitionBeing given responsibility intriguing workAchievementGrowth in the jobEffectiveness of using Herzbergs two-factor theoryHerzberg encouraged managers to study the job itself (nature of tasks, levels of responsibility) rather than conditions of work. Dissatisfaction arise from environment factors-satisfaction can only arise from the job. If there is sufficient challenge, scope and interest in the job, there will be a lasting increase in satisfaction and the employee will work well productivity will be abov e normal levels. the extent to which the job must be challenging or creative in order to provide motivation will depend on each individual, his ability, his expectation and tolerance for slow down success.CONCLUTION
Monday, April 1, 2019
Targeted Drug Delivery for Sex Dependent Cancers
Targeted Drug Delivery for Sex Dependent crabmeatsOccurring genus crab louse in any part of the kind-hearted body such as lung, kidney, cutis and etc. has a different relative incidence ratio between men and women. sex dependent genus crabby persons nominate seen on the dot in male or female which is dependent to sex hormones and specific sex organs such as prostate gland crabby person in male and Ovary and endome running game crappercers in female, front crabby person is seen in both sex with 5% incidence in male. Despite of a self-explaining differentiation between the sex organs, since these organs functions atomic number 18 regulated by same hypothalamic gonadotropin-releasing hormone similarities in cell sign of the zodiacing and pathways via molecular interactions argon eminentlighted for crabby person studies and targeted therapy. Targeted dose pitch for sex dependent cancers has been canvass for many years, but exploring similarities of sex-dependen t cancers targeting could provide an opportunity for future targeted dose auction pitch of these cancers simultaneous effects analysis.Breast CancerBreast cancer (BC) is the most common cancer and ca enforce of dying among women ecumenic during the past decades. To improve diagnosis, therapy and prevention of BC, molecular educations provide mingled techniques for scientist to take away and differentiate BC cell names as well as observe different phenotype of BC. They gradationified BC to three main subtypes oooestrogen/progesterone sensory sensory receptor (ER) electropositive, epidermal return fixings receptor (HER2) positive, and deuce-ace negative chest cancer (TNBC).Estrogen/progesterone receptor (ER) positive In BC subtypes of ER+, the over pull oution of estrogen receptors on meet cells and sum tissue layers induce the over aspiration of estrogen 1. Many studies showed that estrogen receptors could be targeted for anti-cancer delivery to mamilla cells. Some estrogen receptor targeted medicates forthwith use in clinical therapy like tamoxifen from the family of SERMs (selective estrogen receptor modulators) which ar competitive protagonist of the estrogen receptor 2. Arimidex, F beston (Toremifene), Anastrozole, Exemestane, anastrozole, letrozole 3, 4,5Fulvestrant 6argon now in merchandise.Other estrogen receptor targeted medicine is a family of aromatase Inhibitors (AI) that suspend the estrogen production. The third-generation aromatase inhibitors are classified into irreversible steroidal inhibitors and they have shown high authorisation to replace tamoxifen in postmenopausal women such as Exemestane, anastrozole, letrozole2,4 ,5.SERDs (selective estrogen receptor down-regulators) is another estrogen targeted that entirely do drugs with FDA approved is fulvestrant on the name of Faslodex employ in metastatic hormone positive pap cancer 6.HER2 positive This breast cancer subtype is referred to overexpression of erbB2 ( HER2) from the epidermal growth agentive role receptor family on breast cells tissue layers 7. Anti HER2 seasonnt has analyse for targeted therapy of this subtype. Recombinant humanized monoclonal antibody antibodies such as trastuzumab and pertuzumab are widely used for HER2 positive breast cancer and any other HER2 positive cancers 8,9,10. Some monoclonal antibodies are to a lower place further clinical discharges studies like ertumaxomab and margetuximab11.Her2 Vaccine is now under further studies 11.Triple Negative breast cancer (TNBC) These subtype tumors do not express receptors for estrogen or progesterone and not overexpress the HER2 receptor. TNBC is a malignant cancer with the high rate of incidence in younger age and it grows faster with the high electromotive force of metastasis in early stage maculation it is unlikely to be seen on annual mammogram 12. Not only patients with TNBC near show forgetful prognosis compare to other subtypes, but likewise during t herapy they are at the higher risk of relapse, metastasis, and survival 13.Since the clinical running game of some designed drug were not successful, no commercialized drug and therapy for this subtype still exists.Endome running CancerEndometrial Cancer (EC) begins in the uterus cells of the endometrium layer. nighly surgery including hysterectomy (removal of the uterus) and removal of ovaries and lymph nodes is the only way to cure the EC if biopsies show that cancer has not spread, no other treatment is needed. gibe to clinic pathological characteristics, EC is classified to two subtype. Estrogen-dependent endometrioid and estrogen-independent non-endometrioid carcinoma. 14,15. Estrogen-independent EC shows p53 and p16 mutations, overexpression of HER2 and E-cadherin loss 16. Most of the diagnosed EC tumor are estrogen-dependent that express estrogen receptor and hormonal therapy with progestron is a basal line 17. Since EC Type I express estrogen receptor the like ER+ BC ment ioned previously, targeted therapies for EC are SERM, AI and GnRH inhibitors. Tamoxifen (as SERM) and anastrazole (as AI) commonly used. Anti-angiogenesis drugs are efficiently used for EC like Aflibercept, Abitrexate (Methotrexate) is an only trial drug for EC. prostatic CancerProstate cancer is derived from the specific epithelial of secondary sex organs. Todays, the prostate cancer strategies of treatment is mostly base on squashing testosterone level by anti-androgenic, gonadorelin agonist or antagonists 18. Despite of the unknown active mutation in oncogenic pathways in prostate cancers subsets, some molecules express specifically in prostate epithelial cells which have been studied as therapeutic targets including cell outdoors prostate-specific membrane antigen (PSMA), the secreted protease prostate-specific antigen (PSA), and the enzyme prostatic acid phosphatase (PAP).PSMA targeting PSMA is an integral cell surface membrane protein and specifically over-expressed in adva nced prostate cancers. PSMA has been studied in variety II trial as a targeted therapy via monoclonal antibody (J591) blendd with wireless and chemical compounds 19.PSA The prostate-specific antigen (PSA) mostly use as an indicator for primary diagnosis of prostate cancer. Gonadorelin antagonists can suppress testosterone and PSA, by then Degarelix (Firmagon) is now using for treatment in prostate cancer patients. ARN-509 antiandrogen is only used for prostate cancer with high level of PSA indication.PAP prostate acid phosphatase (PAP) is an enzyme produced by prostate and the amount increased in prostate cancer cells. In clinical studies PAP mostly used as an antigen for anti-tumor vaccines 20.ovarian CancerOvarian Cancer is a 5th cause of cancer related death among women worldwide 21.Ovarian cancer has not but been classified. It is poor diagnosed in stage I and in stage II,III,IV diagnosed by metastasis to other organs22. Surgery and aggressive chemotherapy are currently the only way to treat the ovarian cancer. Many studies on targeted therapy for ovarian cancer by nano-carriers are undergoing. Although, in market there is nano-carriers like liposome that carried chemotherapeutical agents like doxorubicin DOXIL (Doxorubicin Hydrochloride Liposome), Evacet (Doxorubicin Hydrochloride Liposome) 23.Novel Targeted therapyAs previously has been mentioned, these cancers are mostly depended on sex hormones level, HER2 expression and other individual molecular marker indications. roughly all chemotherapy regiment have cytotoxic effect on non-cancer cells and caused the chemotherapy aspect effects. If these chemotherapy regiment could be conjugated with marker to specific targets of cancer cells the yield would be cytotoxicity of drug just for cancer cells and no more side effects for healthy cells. This pairing can be followed by protein establish interactions like antigen- antibody mechanism or ligand-receptor affinity. Today novel therapeutical aims are trying to conjugate monoclonal antibodies with drugs which is called antibody-drug conjugated (ADC). Other novel targeted therapy is to conjugate the peptide or protein with drug (PDC). Both ADC and PCD are the subtype of protein drug conjugated approach. The takings of covalent conjugation of drug with antibody or peptide is another novel strategy of prodrug in which after delivered to cells would be cleaved by an enzyme and release active drug 24. For targeted drug delivery for any drugs two main subjects should be considered pallbearer and TargetsCarriersAntibodyIn past decades, targeted drug delivery has been meliorate by development of antibodies against any identified targeted antigen. Not only antibodies can induce uptake of conjugated drug in targeted cells, but also they can conjure up the role of complement-dependant cytotoxicity system to invade targeted cells. The potential of making almost any antigen as a target is an interesting properties of ADCs, however, just few of the human antibodies have shown a longer proper half-lives like IgG1, IgG2, and IgG4. Nearly 40 monoclonal antibodies (mAb) have been approved and develop not only for cancer but also for some autoimmune disease 25. While antibodies have shown low loading capacity of drug, on molecule of antibodies are unfastened to conjugate with less than 3 molecules of drug, for improve ADCs qualification drug should be highly potent.As mentioned previously, HER2 is overexpressed in breast, prostate, ovarian and endometrial cancer that the anti-HER2 antibody can be used for targeted drug delivery. Antibody-drug conjugates (ADC) for HER2 positive is a conjugation of trastuzumab as an antibody and emtansine as cytotoxic compound and commercialized as TDM1. Other cytotoxic compound in conjugation with antibody is under further studies and clinical trial process like defucosylated trastuzumab 26,27. Lapatinib is commercialized drug from the family of sense organ tyrosine kinase inhibitors (R TKI) that target the intracellular binding site of HER and EGFR family 28.In breast cancer antibodies of Anti-LIV1 mAb (hIgG1), Anti-GPNMB mAb (hIgG2), Anti-cripto mAb (hIgG1) in conjugation with drug Auristatin E and DM4 (maytansine) are now clinical human body I. Anti-HER2 mAb (hIgG1) in conjugation with Emtansine-DM1 (maytansine) has been approved in early 2013 and used for metastatic breast cancer. Anti-TROP-2 mAb (mIgG1) in conjugation with SN-38 (irinotecan metabolite) is under further studies for triple negative breast cancer in Phase II clinical 29.In prostate cancer Anti-PSMA mAb (hIgG1) in conjugation with Auristatin E (auristatin) is still on level I clinical 30.IgG1 ADC targets Folate receptor is in Phase 1 studies for ovarian cancer 31.Protein/Peptide-drug conjugated (PDC)Proteins are sequences of amino acids with 3D or 4D social systems that have vital responsibility in all alive cells. Protein has been studied as a carrier for drug due to its stability, longer half -life, biodegradability and unaffixed modification for carry drug with no effect on its wanted function 32. Protein which are widely used as for drug delivery are Transferrin and Albumin 33, Zein 34,Elastin and Gelatine35, Gliadin and Legumin 36.The conjugation of albumin with methotrexate sodium has been studied preclinical for many cancers but it had shown effect on just bone and prostate cancer 37. Conjugation of siderophilin with N-alkylisatin derivatives had shown 10 multiplication more efficient on breast cancer tumor in vivo 38and also conjugation with Artemisinin shown high toxicity for breast cancer in rat 39. Gelatin conjugation with Gallic acid has been studied on prostate cancer 40.Abraxane is an albumin conjugated with paclitaxel in phase I trial for metastatic breast cancer, prostate and ovarian cancer 41.Peptide unremarkably refers to a sequence of amino acids (up to 50) with just up to secondary structure 42. Peptide ligand can be used for targeted receptors. Ho wever, peptides have short half-life and poor stability in serum as they can be debased by protease, but peptides are smaller than antibodies and can easily hue the targeted cells and overcome biological barriers that the allow for would be the fast uptake of drug by targeted cells and also peptides have shown high drug loading potential43.Acyclic RGD4C as peptide c(Cys-Phe-Cys-Asp-Gly-Arg-Cys-Asp-Cys) in conjugation with doxorubicin has been shown higher antitumor exercise on metastatic breast cancer in vivo than doxorubicin alone 44.Targets gonadotrophic hormone hormone receptor targetingThe overexpression of luteinizing hormone releasing hormone (LHRH) receptors has been well report on many cancer tumors specially breast, ovary, endometrial and prostate cancer 45,46. LHRH analog is widely used as a supplementary drug in order to bind to the LHRH receptor 47. LHRH agonist induce downregulation of LHRH and suppress sex steroid hormone. While, LHRH antagonist block the LHRH rece ptors and suppress LHRH and sex steroid releasing immediately 48,49.Prostate cancer drug in market like Degarelix (Firmagon) (ANTAGONISTS), Lupron, Leuprolide Acetate, Zoladex (Goserelin Acetate) are LHRH analog 50.LHRH and its analogue as a peptide with a sequence of 10 amino acids have been studied as a targeted drug carrier. AEZS-108 (formerly known as AN-152) is an LHRH agonist conjugation with doxorubin which is shown anti-cancer activity in phase II clinical trial of gynaecological cancers and a shiny result for prostate cancer 51. LHRH also has been studied for carry cisplatin encapsulated in dextran nano-particle to breast cancer cells 52. Compound uptake via an interaction between LHRH and its receptor and then endocytosis by cell membrane. As normal cells with no overexpression of LHRH receptor could not uptake the drug, side effects of toxic drug significantly has been reduced36.Growth cistron targetingGrowth factor refers to substances that stimulate cells proliferati on and differentiation by binding to their receptors which is tyrosine kinase activate other cell pathways. Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) and their receptors are two class of growth factors that have been studied for targeted therapyAngiogenic pathway targetingIn all cancers, tumor growth and metastasis depend on angiogenesis pathway which activated by vascular endothelial growth factors. VEGF family and their receptors (VEGFR) have been studied for inhibition of tomur growth and metastasis as their overexpression had been seen in most of the malignant cancers 53. The stimulation of VEGF not only induces cells mitosis and terminate apoptosis, but also caused the chemotherapy and actinotherapy immunity 54. On the other hand, chemotherapy and radiotherapy could induce VEGF in tumor cells 55. Hereby, today anti-VEGF drug have been added to chemotherapy regiment.Ovarian cancer cell lines has shown overexpress of VEGFR as well as breast ca ncer cell line like MDA-MB-453, and MDA-MB-231,T-47D,and MCF756. Studies on triple negative breast cancer cell lines MDA-MB-453 have shown that overexpression of VEGF protected cancer cells from apoptosis and improved cell mitosis and invasion 57. Treatment of MDA-MB-453 and MDA-MB-231 with anti-sense oligonucleotide inhibition of VEGF has shown over 50% settle in invasion by Martigel assay 58.Targeting VEGF has been studied in Phase I and II clinical by designing monoclonal anti-body instantaneously against VEGF that shown suppressing metastasis relapsed in patients with breast cancer 59,60,61. Now, Bevacizumab (Avastin) is a monoclonal anti-body that bind to VEGF that has studied in phase III trial for metastasis breast cancer. Successful result has been released in phase III trial studies E2100, AVADO, RIBBON-1 that have Bevacizumab as a supplement and chemotherapy regiment like paclitaxel, docetaxel, anthracycline-based as a first line treatment respectively62,63,64.Epidermal growth factor targetingEpidermal growth factor (EGF) is a factor that induce cell growth, proliferation, differentiation, and survival by binding to its receptor (EGFR) with tyrosine kinase activity. The EGFR from ErbB family (also known as HER) has shown overexpression in cell surface of many cancers, especially breast, prostate, and ovarian cancer. HER2 is a receptor with three domains of extracellular for ligand, transmembrane domain, and cytoplasmic domain with tyrosine kinase activity. The excess of HER2 on cell membrane and high tyrosine kinase activities induce the downstream signalling pathways like PI3K/AKT/mTOR as well as jackass/STAT pathways which suppress apoptosis and promote proliferation and survival. HER2 is overexpressed in 15-30% of invasive breast cancers 65,66,67. Cetuximab (Erbitux) and panitumumab (Vectibix) are the two most advanced monoclonal anti-bodies targeting the extracellular domain of the receptor and inhibit ligand-receptor interaction and tyrosine kinase activity 68,69. But an abnormal form of HER2 which has the drop of extracellular domain, known as P95, is still active but resistance to drug and antibodies that target the extracellular domain70.Antibody-drug conjugates (ADC) for HER2 positive is a conjugation of trastuzumab as an antibody and emtansine as cytotoxic compound and commercialized as TDM1. Other cytotoxic compound in conjugation with antibody is under further studies and clinical trial process like defucosylated trastuzumab26,71. Lapatinib is commercialized drug from the family of Receptor tyrosine kinase inhibitors (RTKI) that target the intracellular binding site of HER and EGFR family 72.References1 Garcia-Becerra R, Santos N, Diaz L, Camacho J. appliances of resistance to endocrine therapy in breast cancer focus on signaling pathways, miRNAs and genetically based resistance. Int J gram molecule Sci. 201214(1)108-45.2 Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998339(22)1609- 18.3 Nabholtz JM, Buzdar A, Pollak M, Harwin W, Burton G, Mangalik A. Anastrozole is select to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol. 200018(22)3758-67.4 Mouridsen HT. Letrozole in advanced breast cancer the PO25 trial. Breast Cancer Res Treat. 2007 one hundred five Suppl 119-29.5 Paridaens RJ, Dirix LY, Beex LV, Nooij M, Cameron DA, Cufer T. Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group. J Clin Oncol. 200826(30)4883-90.6 Osborne CK, Pippen J, Jones SE, Parker LM, Ellis M, Come S. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on anterior endocrine therapy results of a North American trial. J Clin Oncol. 200220(16)3386-95.7 Menard S, Fortis S, Castiglioni F, Agresti R, Balsari A. HER2 as a prognostic factor in breast cancer. Oncology. 200161 Suppl 267-72.8 Baselga J, Albanell J, Molina MA, Arribas J. Mechanism of action of trastuzumab and scientific update. Semin Oncol. 200128(5 Suppl 16)4-11.9 Gennari R, Menard S, Fagnoni F, Ponchio L, Scelsi M, Tagliabue E. Pilot study of the mechanism of action of operative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res. 200410(17)5650-5.10 Baselga J, Cortes J, Im SA, Clark E, Ross G, Kiermaier A. Biomarker analyses in CLEOPATRA a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer. J Clin Oncol. 201432(33)3753-61.11 Toss A, Cristofanilli M. Molecular delineation and targeted therapeutic approaches in breast cancer. Breast Cancer Res. 2015176 0.12 Jamdde VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N. alterative targets of triple-negative breast cancer a followup. Br J Pharmacol. 2015172(17)4228-37.13 Mustacchi G, De Laurentiis M. The role of taxanes in triple-negative breast cancer literature review. Drug Des Devel Ther. 201594303-18.14 -Cancer Genome map collection Research N, Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y. Integrated genomic characterization of endometrial carcinoma. Nature 2013 497(7447)67e73.15 Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 198315(1)10e7.16 Silva JL, Paulino E, Dias MF, Melo AC. Endometrial cancer redefining the molecular-targeted approach. Cancer Chemother Pharmacol. 201576(1)1e11.17 Zhang Y, Zhao D, Gong C, Zhang F, He J, Zhang W. omen role of hormone receptors in endometrial cancer a authoritative review and meta-analysis. World J Surg Oncol. 201513208.18 -Obinata D, Takayama K, Takahashi S, Inoue S. Crosstalk of the Androgen Recepto r with Transcriptional Collaborators Potential Therapeutic Targets for Castration-Resistant Prostate Cancer. Cancers (Basel) Internet. 20179(3)22.19 Fernandez-Garcia EM, Vera-Badillo FE, Perez-Valderrama B, Matos-Pita AS, Duran I. Immunotherapy in prostate cancer review of the current evidence. Clin Transl Oncol. 2014339-57.20 Becker JT, Olson BM, Johnson LE, Davies JG, Dunphy EJ, McNeel DG. DNA vaccine encoding prostatic acid phosphatase (PAP) elicits semipermanent T-cell responses in patients with recurrent prostate cancer. J Immunother. 201033(6)639-47.21 Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008 GLOBOCAN 2008. Int. J. Cancer. 2010 1272893-2917.22 -Bast RC, Hennessy B, Mills GB. The biology of ovarian cancer new opportunities for translation. Nat Rev Cancer. 20099415-28.23 Delie F, Allemann E, Cohen M. Nanocarriers for ovarian cancer active drug targeting. J Drug Deliv Sci Technol. 201222(5)421-6.24 Hamada Y. Re cent progress in prodrug design strategies based on generally applicable modifications. Bioorg Med Chem Lett Internet. 201727(8)1627-32.25 -Ishii M. Immunology provides a great success for treating general autoimmune diseases a perspective on immunopharmacology IUPHAR Review X. Br J Pharmacol Internet. 2017.26 Lewis Phillips GD Li G, Dugger DL, Crocker LM, Parsons KL, Mai E, Blttler WA, Lambert JM, Chari RV, Lutz RJ, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008 689280-9290.27 LoRusso, PM, Weiss D, Guardino E, Girish S, Sliwkowski MX. Trastuzumab emtansine A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res. 2011 176437-6447.28 Rosen, L.S. Ashurst, H.L. Chap, L. Targeting signal transduction pathways in metastatic breast cancer A comprehensive review. Oncologist. 2010 5216-235.29 -Cardillo TM, Govindan SV, Sharkey RM, Trisal P, Gold enberg DM. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res.2011 17 3157-69.30 -DiPippo VA, Olson WC, Nguyen HM, Brown LG, Vessella RL, Corey E. readiness studies of an antibody-drug conjugate PSMA-ADC in patient-derived prostate cancer xenografts. Prostate. 201575(3)303-13.31 Borghaei H, OMalley DM, Seward SM, et al. Phase 1 study of IMGN853, a folate receptor alpha (FR)-targeting antibody-drug conjugate (ADC) in patients (Pts) with epithelial ovarian cancer (EOC) and other FRA-positive solid tumors. Proc Am Soc Clin Oncol.2015 33 (suppl) abstr5558.32 weber C, Coester C, Kreuter J, LangerK. Desolvation process and surface characterisation of protein nanoparticles. International Journal of Pharmaceutics, 2000194(1)91-102.33 Kratz F. Albumin as a drug carrier design of prodrugs, drug conjugates and nanoparticles. Journal of Controlled Release.2008132(3) 171-181.34 Podaralla S, Perumal O. readiness of zein nanoparticles by pH controlled nanoprecipitation. Journal of Biomedical Nanotechnology. 20106(4)312-7.35 Babaei Z, Jahanshahi J,Sanati MH. Fabrication and evaluation of gel nanoparticles for delivering of anticancer drug. International Journal of NanoScience and Nanotechnology. 2008423-9.36 Arangoa MA, Campanero MA, Renedo MJ, Ponchel G, Irache JM. Gliadin nanoparticles as carriers for the oral establishment of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics. Pharmaceutical Research. 200118(1)1521-7.37 -Burger AM, Hartung G, Stehle G, Sinn H, Fiebig HH. Pre-clinical evaluation of a methotrexate-albumin conjugate (MTX-HSA) in human tumor xenografts in vivo. Int J Cancer. 200192(5)718-24.38 Indira Chandran V, Matesic L, Locke JM, Skropeta D, Ranson M, Vine KL. Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor. Cancer Lett. 2012316(2)151-6.39 Lai H, Nakas e I, Lacoste E, Singh NP, Sasaki T. Artemisinin-transferrin conjugate retards growth of breast tumors in the rat. Anticancer Res. 200929(10)3807-10.40 -Cirillo G, Kraemer K, Fuessel S, Puoci F, Curcio M, Spizzirri UG, et al. biological activity of a gallic acid-gelatin conjugate. Biomacromolecules. 201011(12)3309-15.41 -Nyman DW, Campbell KJ, Hersh E, Long K, Richardson K, Trieu V, et al. Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies. J Clin Oncol. 200523(31)7785-93.42 A.K. Sato, M. Viswanathan, R.B. Kent, C.R. Wood,
Subscribe to:
Posts (Atom)